Article

Learning transcriptome architecture from sequence with a long-context RNA foundation model

2024-08-27

Abstract excerpt

Linking DNA sequence to genomic function remains one of the grand challenges in genetics and genomics. Here, we present a large-scale compendium of single-molecule transcriptome sequencing of diverse cancer cell lines, revealing their isoform diversity and specificity. We used this compendium to build Mach-1, an RNA foundation model that learns how the nucleotide sequence of unspliced pre-mRNA dictates transcripto...

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Literature Corpus work: 10c04a1e-8adc-5db2-a204-1c76e51ae98c
DOI: 10.1101/2024.08.26.609813

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