Article

Using single-cell perturbation screens to decode the regulatory architecture of splicing factor programs

2025-02-08

Abstract excerpt

<h4>SUMMARY</h4> Splicing factors shape the isoform pool of most transcribed genes, playing a critical role in cellular physiology. Their dysregulation is a hallmark of diseases like cancer, where aberrant splicing contributes to progression. While exon inclusion signatures accurately assess changes in splicing factor activity, systematically mapping disease-driver regulatory interactions at scale remains challen...

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Literature Corpus work: be68931c-6a83-5f3c-8a47-e9f271142970
DOI: 10.1101/2025.02.07.637061

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