Article

PARP1 Suppression Drives ROS Resistance in Aneuploid Cancer Cells

2025-08-16

Abstract excerpt

<h4>Summary</h4> Aneuploidy—defined as gains and losses of chromosomes—is frequently observed in cancer and has been implicated in promoting tumor progression and metastasis. However, the molecular mechanisms underlying this phenomenon remain poorly understood. By generating new models of aneuploidy, we found that aneuploidy confers remarkable resistance to reactive oxygen species (ROS)-mediated cell death. This...

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Literature Corpus work: 8d6cd846-59a2-5711-bf5f-ee67a7dfd64b
DOI: 10.1101/2025.08.13.670212

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