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Article

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

1 Apr 2018

Abstract excerpt

Aneuploidy, whole chromosome or chromosome arm imbalance, is a near-universal characteristic of human cancers. In 10,522 cancer genomes from The Cancer Genome Atlas, aneuploidy was correlated with TP53 mutation, somatic mutation rate, and expression of proliferation genes. Aneuploidy was anti-correlated with expression of immune signaling genes, due to decreased leukocyte infiltrates in high-aneuploidy samples....

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PMID: 29622463
DOI: 10.1016/j.ccell.2018.03.007

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