Article

Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice

2019-06-13

Abstract excerpt

<title>Abstract</title> <p>The tauopathy-like phenotype observed in the rTg4510 mouse line, in which human tau<sub>P301L</sub> expression specifically within the forebrain can be temporally controlled, has largely been attributed to high overexpression of mutant human tau in the forebrain region. Unexpectedly, we found that in a different mouse line with a targeted-insertion of the same transgene driven by the sa...

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Literature Corpus work: ac52b703-45c5-54a3-807d-748fc0edd8af
DOI: 10.21203/rs.2.1788/v1

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