Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice

Abstract excerpt

expression specifically within the forebrain can be temporally controlled, has largely been attributed to high overexpression of mutant human tau in the forebrain region. Unexpectedly, we found that in a different mouse line with a targeted-insertion of the same transgene driven by the same tetracycline-TransActivator (tTA) allele, but with even higher overexpression of tauP301L than rTg4510, atrophy and tau...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alzheimer's disease research and treatments
• Share to Calpain Protease Function and Regulation
• Share to Neuroinflammation and Neurodegeneration Mechanisms