Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Developmental Pathogenicity of 4-Repeat Human Tau Is Lost with the P301L Mutation in Genetically Matched Tau-Transgenic Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Jan 2020

Gamache Julia E, Kemper Lisa, Steuer Elizabeth, Leinonen-Wright Kailee, Choquette Jessica M, Hlynialuk Chris, Benzow Kellie, Vossel Keith A, Xia Weiming, Koob Michael D, Ashe Karen H

Abstract excerpt

Tau is a microtubule-associated protein that becomes dysregulated in a group of neurodegenerative diseases called tauopathies. Differential tau isoforms, expression levels, promoters, and disruption of endogenous genes in transgenic mouse models of tauopathy make it difficult to draw definitive conclusions about the biological role of tau in these models. We addressed this shortcoming by characterizing the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Synthetic
Share to INDEL Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Maze Learning

Share to Memory Disorders

Share to Microtubules

Share to Mitochondrial Diseases

Share to Prosencephalon

Share to Repetitive Sequences, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 31685653
DOI: 10.1523/JNEUROSCI.1256-19.2019
PMCID: PMC6939485

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Developmental Pathogenicity of 4-Repeat Human Tau Is Lost with the P301L Mutation in Genetically Matched Tau-Transgenic Mice.PMID 31685653Read ↗

The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition.Semantic proximity Read ↗

Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 miceSemantic proximity Read ↗

Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)Semantic proximity Read ↗

Limitations of human tau-expressing mouse models and novel approaches of mouse modeling for tauopathySemantic proximity Read ↗

Characterization of a novel transgenic rat carrying human tau with mutation P301L.Semantic proximity Read ↗

Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 miceSemantic proximity Read ↗

Distinct mechanistic pathways of early tauopathy revealed by <i>MAPT</i> mutationsSemantic proximity Read ↗

Characterization of Pathology in Transgenic Mice Over-Expressing Human Genomic and cDNA Tau TransgenesSemantic proximity Read ↗

Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagationSemantic proximity Read ↗

Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation.Semantic proximity Read ↗

Distinct mechanistic pathways of early tauopathy revealed by MAPT mutationsSemantic proximity Read ↗

Neuronal loss and inflammation preceding fibrillary tau pathology in a rat model with early human-like tauopathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.