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Article

Characterization of a novel transgenic rat carrying human tau with mutation P301L.

Neurobiology of aging - 1 Dec 2011

Korhonen P, van Groen T, Thornell A, Kyrylenko S, Soininen M-L, Ojala J, Peltomaa E, Tanila H, Salminen A, Mandelkow E M, Soininen H

Abstract excerpt

We have established a novel transgenic rat line carrying human microtubule-associated protein Tau-40 with mutation P301L. hTau-40/P301L transgenic male and female rats were followed up to 2 years of age. The hTau-40/P301L rats expressed human tau mRNA and protein in the limbic cortex and associated white matter, hippocampus and spinal cord. With increasing age, the staining density for phosphorylated tau...

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Identifiers

PMID: 20097445
DOI: 10.1016/j.neurobiolaging.2009.12.022

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