Article
Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.
Neuro-degenerative diseases - 1 Jan 2013
Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, Schofield E L, Ward M A, Posch M, Jungwirth H, Windisch M, Hutter-Paier B
Abstract excerpt
Tauopathies, characterized by hyperphosphorylation and aggregation of tau protein, include frontotemporal dementias and Alzheimer's disease. To explore disease mechanisms and investigate potential treatments, we generated a transgenic (tg) mouse line overexpressing human tau441 with V337M and R40...
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