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A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau

10 Nov 2023

Abstract excerpt

BACKGROUND: Intraneuronal accumulation of hyperphosphorylated tau is a defining hallmark of Alzheimer's disease (AD). However, mouse models imitating AD-exclusive neuronal tau pathologies are lacking. METHODS: We generated a new tet-on transgenic mouse model expressing truncated human tau N1-368 (termed hTau368), a tau fragment increased in the brains of AD patients and aged mouse brains. Doxycycline (dox) was...

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PMID: 37950283
DOI: 10.1186/s40035-023-00379-5

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