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Article

Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy

6 Apr 2018

Abstract excerpt

Although tau pathology, behavioral deficits, and neuronal loss are observed in patients with tauopathies, the relationship between these endpoints has not been clearly established. Here we found that rTg4510 mice, which overexpress human mutant tau in the forebrain, develop progressive age-dependent increases in locomotor activity (LMA), which correlates with neurofibrillary tangle (NFT) pathology,...

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PMID: 29624602
DOI: 10.1371/journal.pone.0195486

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