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Limitations of human tau-expressing mouse models and novel approaches of mouse modeling for tauopathy

20 Apr 2023

Abstract excerpt

Neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein are primarily neuropathological features of a number of neurodegenerative diseases, collectively termed tauopathy. There is no disease-modifying drug available for tauopathy except anti-amyloid antibody therapies for Alzheimer's disease. For tau-targeting therapy, experimental models recapitulating human tau pathologies are indispensable....

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Identifiers

PMID: 37152607
DOI: 10.3389/fnins.2023.1149761

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