Article

A motif preferred adenine base editor with minimal bystander and off-targets editing

2024-11-24

Abstract excerpt

48% of hereditary disease are caused by single C-to-T base conversion, which makes efficient A-to-G base editing tools (ABEs) have great potential in the treatment of these diseases. However, the existing efficient ABE, while catalyzing A-to-G conversion, will bring more A and C bystander editing and off-target events, which poses safety concerns for their clinical application. Here, we developed ABE10 (ABE8e with...

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Identifiers and source

Literature Corpus work: ac4e8110-009d-510e-823c-ceab75f1e0e6
DOI: 10.1101/2024.11.23.624961

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