Article
A/C Simultaneous Conversion Using the Dual Base Editor in Human Cells.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023
Zhang Xiaohui, Guan Yuting, Li Dali
Abstract excerpt
Base editors, mostly cytidine base editors (CBEs) and adenine base editors (ABEs), are powerful tools for precise base editing. However, current base editors can only edit either adenines or cytosines. Thus, our lab has developed a dual base editor (A&C-BEmax) through the fusion of cytidine and adenosine deaminases to Cas9n to achieve both C•G to T•A and A•T to G•C mutations, which enables A/C simultaneous...
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