Article

An AI-designed adenine base editor

2024-04-29

Abstract excerpt

Adenine base editors (ABEs) allow the efficient programmable conversion of adenine to guanine without causing DNA double strand breaks. Previous ABEs were generated by multiple rounds of directed evolution or derived by rational design based on the evolved ones. Although powerful, these methods search the local space for ABEs optimizations. Artificial intelligence (AI) based methods have the ability to efficiently...

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Literature Corpus work: 7a4effe4-fcb9-516f-86e6-d2f3255b79bd
DOI: 10.1101/2024.04.28.591233

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