Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Precision A3G base editors for disease modeling and correction.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Apr 2026

Zeng Hongzhi, Liu Aidi, Daniel Tyler C, Golla Devin A, Lu Zhenyu, Serodio Rebecca, Millette Brigid A, Lingineni Ananya, Gilberd Peretz, Chee Kelly, Talloo Komal, Peddi Advaith, Park So Hyun, Bao Gang, Gao Xue

Abstract excerpt

Cytosine base editors (CBEs) enable efficient cytosine-to-thymine substitutions at targeted genomic loci without introducing double-stranded breaks. Among CBEs, APOBEC3G BEs (A3G-BEs) preferentially edit the second cytosine within a 5'-CC-3' motif in human cells, reducing potential bystander editing. However, A3G-BEs often unintentionally edit multiple CC motifs within their editing window and are limited by...

Topics

Join the communities discussing this publication.

Gene Editing
APOBEC-3G Deaminase
CRISPR-Cas Systems
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 41536070
DOI: 10.1016/j.ymthe.2026.01.003
PMCID: PMC12934557

Genes

PAM
APOBEC3G

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Precision A3G base editors for disease modeling and correction.PMID 41536070Read ↗

Engineering a precise adenine base editor with minimal bystander editing.Semantic proximity Read ↗

Precise and programmable C:G to G:C base editing in genomic DNASemantic proximity Read ↗

A motif preferred adenine base editor with minimal bystander and off-targets editingSemantic proximity Read ↗

A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects.Semantic proximity Read ↗

Enhancing glycosylase base-editor activity by fusion to transactivation modules.Semantic proximity Read ↗

Advances in base editing: A focus on base transversions.Semantic proximity Read ↗

Engineering precise adenine base editor with infinitesimal rates of bystander mutations and off-target editingSemantic proximity Read ↗

Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activitySemantic proximity Read ↗

An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities.Semantic proximity Read ↗

Single‐nucleotide editing: From principle, optimization to applicationSemantic proximity Read ↗

Precision genome editing using cytosine and adenine base editors in mammalian cells.Semantic proximity Read ↗

Towards optimizing diversifying base editors for high-throughput studies of single- nucleotide variantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.