Article
A precise and efficient adenine base editor.
Molecular therapy : the journal of the American Society of Gene Therapy - 7 Sept 2022
Tu Tianxiang, Song Zongming, Liu Xiaoyu, Wang Shengxing, He Xiaoxue, Xi Haitao, Wang Jiahua, Yan Tong, Chen Haoran, Zhang Zhenwu, Lv Xiujuan, Lv Jineng, Huang Xiu-Feng, Zhao Junzhao, Lin Chao-Po, Gao Caixia, Zhang Jinwei, Gu Feng
Abstract excerpt
Adenine base editors (ABEs) are novel genome-editing tools, and their activity has been greatly enhanced by eight additional mutations, thus named ABE8e. However, elevated catalytic activity was concomitant with frequent generation of bystander mutations. This bystander effect precludes its safe applications required in human gene therapy. To develop next-generation ABEs that are both catalytically efficient and...
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