Article

An RNA degradation complex required for silencing of Polycomb target genes

2019-12-24

Abstract excerpt

Polycomb Repressive Complex (PRC) 1 and 2 are histone-modifying and chromatin-binding complexes that are required for silencing of developmental regulatory genes and genes that control cellular proliferation. Their gene silencing functions are thought to involve chromatin compaction and condensate formation but whether other mechanisms contribute to silencing is unknown. Here we show that the rixosome, a conserved...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ac27d3fa-e809-5f7a-90f4-234109ba3fba
DOI: 10.1101/2019.12.23.887547

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An RNA degradation complex required for silencing of Polycomb target genesDOI 10.1101/2019.12.23.887547Read

From genetics to epigenetics: the tale of Polycomb group and trithorax group genes.Semantic proximity Read

The RING1 subunit of Polycomb Repressive Complex 1 monoubiquitinates histone H2A and mediates repression independently of Polycomb Repressive Complex 2 in the model diatom Phaeodactylum tricornutum.Semantic proximity Read

Chromatin interaction analyses elucidate the roles of PRC2-bound silencers in mouse development.Semantic proximity Read

Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination.Semantic proximity Read

Epigenetic balance of gene expression by Polycomb and COMPASS families.Semantic proximity Read

Analysis of a polycomb group protein defines regions that link repressive activity on nucleosomal templates to in vivo function.Semantic proximity Read

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.Semantic proximity Read

Dynamic Chromatin Remodeling Mediated by Polycomb Proteins Orchestrates Pancreatic Differentiation of Human Embryonic Stem CellsSemantic proximity Read

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells.Semantic proximity Read

Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains.Semantic proximity Read

Long noncoding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression.Semantic proximity Read

Histone acetylation and the maintenance of chromatin compaction by Polycomb repressive complexes.Semantic proximity Read