Article
Histone acetylation and the maintenance of chromatin compaction by Polycomb repressive complexes.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 2010
Eskeland R, Freyer E, Leeb M, Wutz A, Bickmore W A
Abstract excerpt
Mechanisms controlling higher-order chromatin structure or chromatin compaction and linking this to gene regulation are poorly understood. Previously, we had shown that the PRC1 Polycomb repressive complex is required to maintain a compact chromatin state at Polycomb target loci in embryonic stem cells (ESCs) of the mouse and that this activity, together with the ability to repress target gene expression, is...
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