Long noncoding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression.

doi:10.1158/0008-5472.CAN-10-4379

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Article

Long noncoding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression.

Cancer research - 15 Aug 2011

Aguilo Francesca, Zhou Ming-Ming, Walsh Martin J

Abstract excerpt

Polycomb group proteins (PcG) function as transcriptional repressors of gene expression. The important role of PcG in mediating repression of the INK4b-ARF-INK4a locus, by directly binding to the long noncoding RNA (lncRNA) transcript antisense noncoding RNA in the INK4 locus (ANRIL), was recently shown. INK4b-ARF-INK4a encodes 3 tumor-suppressor proteins, p15(INK4b), p14(ARF), and p16(INK4a), and its...

Topics

Animals
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16
Gene Silencing
Genetic Predisposition to Disease
Humans
Multigene Family
Polycomb Repressive Complex 1
RNA, Untranslated
Repressor Proteins
Transcription, Genetic
Tumor Suppressor Protein p14ARF

Source

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Identifiers

PMID: 21828241
DOI: 10.1158/0008-5472.CAN-10-4379
PMCID: PMC3339196

Genes

PRC1

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