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Article

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells.

Blood - 5 Aug 2010

Majewski Ian J, Ritchie Matthew E, Phipson Belinda, Corbin Jason, Pakusch Miha, Ebert Anja, Busslinger Meinrad, Koseki Haruhiko, Hu Yifang, Smyth Gordon K, Alexander Warren S, Hilton Douglas J, Blewitt Marnie E

Abstract excerpt

Polycomb group (PcG) proteins are transcriptional repressors with a central role in the establishment and maintenance of gene expression patterns during development. We have investigated the role of polycomb repressive complexes (PRCs) in hematopoietic stem cells (HSCs) and progenitor populations. We show that mice with loss of function mutations in PRC2 components display enhanced HSC/progenitor population...

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Source

Identifiers

PMID: 20445021
DOI: 10.1182/blood-2009-12-260760

Genes

PRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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