Article

Aberrant FICD-mediated AMPylation drives α-Synuclein pathology and overall protein dyshomeostasis in dopaminergic neurons in Parkinson’s disease

2026-04-01

Abstract excerpt

<h4>Background</h4> Filamentation induced by cAMP domain-containing protein (FICD) is an endoplasmic reticulum (ER)-resident adenylyltransferase that catalyzes protein AMPylation, a post-translational modification. Although FICD-mediated AMPylation has been linked to the fine-tuning of proteostasis and neuronal integrity, its role in neurodegenerative diseases characterized by protein dyshomeostasis remains uncle...

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Literature Corpus work: ac0c7ec9-a809-5d10-ade1-f79887455237
DOI: 10.64898/2026.03.30.715195

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