Article

Alpha-Synuclein is a Target of Fic-mediated Adenylylation/AMPylation: Implications for Parkinson’s Disease

2019-01-21

Abstract excerpt

<h4>ABSTRACT</h4> During disease, cells experience various stresses that manifest as an accumulation of misfolded proteins and eventually lead to cell death. To combat this stress, cells activate a pathway called UPR (Unfolded Protein Response) that functions to maintain ER (endoplasmic reticulum) homeostasis and determines cell fate. We recently reported a hitherto unknown mechanism of regulating ER stress via a...

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Literature Corpus work: a6107274-b429-5b77-b891-6dfb03e45b54
DOI: 10.1101/525659

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