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FicD Sensitizes Cellular Response to Glucose Fluctuations in Mouse Embryonic Fibroblasts

2024-01-23

Abstract excerpt

During homeostasis, the endoplasmic reticulum (ER) maintains productive transmembrane and secretory protein folding that is vital for proper cellular function. The ER-resident HSP70 chaperone, BiP, plays a pivotal role in sensing ER stress to activate the unfolded protein response (UPR). BiP function is regulated by the bifunctional enzyme FicD that mediates AMPylation and deAMPylation of BiP in response to change...

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Literature Corpus work
99eaf64e-78f4-5630-91ed-135dea9671ff
DOI
10.1101/2024.01.22.576705
Open publication

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FicD Sensitizes Cellular Response to Glucose Fluctuations in Mouse Embryonic FibroblastsDOI 10.1101/2024.01.22.576705
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