Article

Intermolecular disulfide-bond formation in human FICD modulates the activity of the hyperactive E234G mutant

2017-04-11

Abstract excerpt

Endoplasmic reticulum (ER) stress that leads to the accumulation of misfolded proteins in the ER initiates the unfolded protein response (UPR). This homeostatic response activates signaling pathways that seek to reinstate a proper ER protein folding balance or induce apoptosis if ER stress persists. Recently, we and others identified human FICD (Filamentation induced by cyclic AMP domain-containing protein), an en...

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Literature Corpus work: d3814ea3-6718-5230-a219-7710f40430e4
DOI: 10.1101/126516

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