Article

Small molecule FICD inhibitors suppress endogenous and pathologic FICD-mediated protein AMPylation

2024-07-16

Abstract excerpt

<h4>Summary</h4> The AMP transferase, FICD, is an emerging drug target finetuning stress signaling in the endoplasmic reticulum (ER). FICD is a bi-functional enzyme, catalyzing both AMP addition (AMPylation) and removal (deAMPylation) from the ER resident chaperone BiP/GRP78. Despite increasing evidence linking excessive BiP/GRP78 AMPylation to human diseases, small molecules to inhibit pathogenic FICD variants a...

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Literature Corpus work: 86cf115c-ea5a-5044-a6dd-c9fcb78fc6dc
DOI: 10.1101/2024.07.13.603377

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