Article
Fic-mediated AMPylation tempers the unfolded protein response during physiological stress.
Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2022
Casey Amanda K, Gray Hillery F, Chimalapati Suneeta, Hernandez Genaro, Moehlman Andrew T, Stewart Nathan, Fields Hazel A, Gulen Burak, Servage Kelly A, Stefanius Karoliina, Blevins Aubrie, Evers Bret M, Krämer Helmut, Orth Kim
Abstract excerpt
The proper balance of synthesis, folding, modification, and degradation of proteins, also known as protein homeostasis, is vital to cellular health and function. The unfolded protein response (UPR) is activated when the mechanisms maintaining protein homeostasis in the endoplasmic reticulum become overwhelmed. However, prolonged or strong UPR responses can result in elevated inflammation and cellular damage....
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