Article

Inhibition of FicD-mediated AMPylation and deAMPylation by Isoprenoid Diphosphates

2025-12-08

Abstract excerpt

FicD regulates Unfolded Protein Response (UPR) through reversible AMPylation and deAMPylation of BiP, an HSP70 chaperone and master regulator of the UPR. FicD activity is regulated by ER-stress, catalyzing BiP AMPylation under low stress conditions to hold inactive chaperone in reserve. In stressed cells, FicD deAMPylates BiP, acutely increasing its active pool to assist in protein folding. Variants in UPR machine...

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Literature Corpus work: ec263be1-ccc2-5f0d-90c8-99d508d1a3e7
DOI: 10.64898/2025.12.08.693056

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