Back to search

Article

Phosphoproteomic profiling reveals post-translational dysregulation in Huntington’s disease patient-derived neurons

2025-10-26

Abstract excerpt

<h4>ABSTRACT</h4> Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion in the Huntingtin ( HTT ) gene. Although transcriptomic and proteomic changes have been characterized in patient-derived neurons, the contribution of post-translational modifications (PTMs), such as phosphorylation, remains poorly understood. Here, we present the first phosphoproteomic analysis by...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f743201c-0cae-5d98-b4fd-54b05dd8ba85
DOI
10.1101/2025.10.24.684372
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Phosphoproteomic profiling reveals post-translational dysregulation in Huntington’s disease patient-derived neuronsDOI 10.1101/2025.10.24.684372
Proteomic Analysis of Huntington’s Disease Medium Spiny Neurons Identifies Alterations in Lipid DropletsSemantic proximity
How Do Post-Translational Modifications Influence the Pathomechanistic Landscape of Huntington's Disease? A Comprehensive Review.Semantic proximity
A novel post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s disease <i>GBA-N370S</i> dopamine neuronsSemantic proximity
Temporal dynamics of proteome and phosphorproteome during neuronal differentiation in the reference KOLF2.1J iPSC lineSemantic proximity
A human huntingtin SNP alters post-translational modification and pathogenic proteolysis of the protein causing Huntington diseaseSemantic proximity
A human huntingtin SNP alters post-translational modification and pathogenic proteolysis of the protein causing Huntington disease.Semantic proximity
Abnormal molecular signatures of inflammation, energy metabolism and vesicle biology in human Huntington disease peripheral tissuesSemantic proximity
Phospho-signalling deregulation of the mTOR pathway in fibroblasts from LRRK2 Parkinson’s patientsSemantic proximity
Modulation of huntingtin S421 phosphorylation in a Huntington’s disease mouse model and its detection in nonhuman primate cerebrospinal fluidSemantic proximity
The Cellular and Extra-Cellular Proteomic Signature of Human Dopaminergic Neurons Carrying the LRRK2 G2019S MutationSemantic proximity
Multimodal spatial transcriptomics determines repeat expansion, huntingtin aggregation, and selective cortical neuron loss in Huntington’s DiseaseSemantic proximity
Current Technologies Unraveling the Significance of Post-Translational Modifications (PTMs) as Crucial Players in NeurodegenerationSemantic proximity
Select a neighboring publication to make it the new centre.