Article

AMPylation regulates PLD3 processing

2025-01-09

Abstract excerpt

The 5’-3’ exonuclease phospholipase D3 (PLD3) is a single-pass transmembrane protein undergoing sequential post-translational modifications (PTM) by N -glycosylation, AMPylation and proteolytic cleavage. The substrates of PLD3 5’-3’ exonuclease activity are single-stranded DNAs and RNAs, which act as ligands for Toll-like receptors (TLRs) and trigger a downstream pro-inflammatory response. Although PLD3 has prima...

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Literature Corpus work: 11dc4390-02f0-5dbb-bdbd-755227d77020
DOI: 10.1101/2025.01.09.632087

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