Article

dAux orchestrates the phosphorylation-dependent assembly of the lysosomal V-ATPase in glia and contributes to α-synuclein degradation

2023-12-08

Abstract excerpt

Glia serve as double-edged swords to modulate neuropathology in Parkinson’s disease (PD), but how they react opposingly to be beneficial or detrimental under pathological conditions, like promoting or eliminating α-synuclein (α-syn) inclusions, remains elusive. Here we present evidence that dAuxilin (dAux), the Drosophila homolog of the PD risk factor Cyclin G-associated kinase (GAK), regulates the lysosomal degr...

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Identifiers and source

Literature Corpus work: 7857f494-4c06-5793-90d2-ec7bb302c8fa
DOI: 10.1101/2023.12.07.570521

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