Article

Paraspeckle Protein NONO Regulates Active Chromatin by Allosterically Stimulating NSD1

2025-01-21

Abstract excerpt

<h4>SUMMARY</h4> NSD1 is a key lysine methyltransferase for di-methylation of lysine 36 of histone H3 (H3K36me2) essential for the establishment of active chromatin domains. While the loss of NSD1 catalytic activity halts embryonic development and a gain of that drives oncogenesis in leukemia and glioma, the regulatory mechanisms that control NSD1 activity in these processes remain poorly understood. Here, we unc...

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Literature Corpus work: 357111d5-ddd4-5e94-8aaf-9c5e1433be76
DOI: 10.1101/2025.01.21.634125

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