Article

NONO as a Sensor of Intracellular Oxidation: Relevance to Neuroblastoma Cell Death

2025-10-31

Abstract excerpt

Neuroblastoma, a transcriptionally driven pediatric malignancy, exhibits a remarkable clinical and biological heterogeneity. Two major subtypes, the adrenergic and mesenchymal, are differentially governed by a subset of transcription factors that comprise the core regulatory circuit (CRC). The former subtype is often associated with MYCN amplification and is particularly aggressive and therapy-resistant, undersco...

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Literature Corpus work: 9df953b1-68df-5f6a-bef6-71f511f59b46
DOI: 10.1101/2025.10.30.685543

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