Super enhancers define regulatory subtypes and cell identity in neuroblastoma.

doi:10.1038/s43018-020-00145-w

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Article

Super enhancers define regulatory subtypes and cell identity in neuroblastoma.

Nature cancer - 1 Jan 2021

Gartlgruber Moritz, Sharma Ashwini Kumar, Quintero Andrés, Dreidax Daniel, Jansky Selina, Park Young-Gyu, Kreth Sina, Meder Johanna, Doncevic Daria, Saary Paul, Toprak Umut H, Ishaque Naveed, Afanasyeva Elena, Wecht Elisa, Koster Jan, Versteeg Rogier, Grünewald Thomas G P, Jones David T W, Pfister Stefan M, Henrich Kai-Oliver, van Nes Johan, Herrmann Carl, Westermann Frank

Abstract excerpt

Half of the children diagnosed with neuroblastoma (NB) have high-risk disease, disproportionately contributing to overall childhood cancer-related deaths. In addition to recurrent gene mutations, there is increasing evidence supporting the role of epigenetic deregulation in disease pathogenesis. Yet, comprehensive cis-regulatory network descriptions from NB are lacking. Here, using genome-wide H3K27ac profiles...

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PMID: 35121888
DOI: 10.1038/s43018-020-00145-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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