Article

Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts

2023-07-14

Abstract excerpt

<h4>ABSTRACT</h4> RNA-binding proteins (RBPs) stimulate the DNA damage response (DDR). The RBP NONO marks nuclear paraspeckles in unperturbed cells and undergoes poorly understood re-localisation to the nucleolus upon induction of DNA double-strand breaks (DSBs). Here we show that treatment with the topoisomerase-II inhibitor etoposide stimulates the production of RNA polymerase II-dependent, DNA damage-induced n...

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Literature Corpus work: 39c57227-6478-59d2-b1ad-4256006eba2e
DOI: 10.1101/2023.07.14.548979

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