Article

Saying “Yes” to NONO: A Target for Neuroblastoma Therapy?

2025-09-04

Abstract excerpt

Pediatric tumors such as neuroblastoma are characterized by a genome-wide ‘transcrip-tional burden’ surmising the involvement of multiple alterations of gene expression. Search for master regulators of transcription whose inactivation is lethal for tumor cells identified the non-POU domain-containing octamer-binding protein (NONO), a member of the Drosophila Behavior/Human Splicing family known for the ability to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 31c73b88-a3d4-5f17-9602-d99976678b7e
DOI: 10.20944/preprints202509.0314.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Saying “Yes” to NONO: A Target for Neuroblastoma Therapy?DOI 10.20944/preprints202509.0314.v1Read

RNA binding is essential for NONO condensates to modulate pre-mRNA processing of super enhancer-associated genes in neuroblastomaSemantic proximity Read

Stable interaction of NONO with DBHS family members upon etoposide-induced DNA damageSemantic proximity Read

NONO as a Sensor of Intracellular Oxidation: Relevance to Neuroblastoma Cell DeathSemantic proximity Read

Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects.Semantic proximity Read

Further delineation of the phenotypic spectrum associated with hemizygous loss-of-function variants in NONO.Semantic proximity Read

Transcriptional silencing of fetal hemoglobin expression by NonOSemantic proximity Read

Paraspeckle Protein NONO Regulates Active Chromatin by Allosterically Stimulating NSD1Semantic proximity Read

Examining the potential involvement of NONO in TDP-43 proteinopathy in DrosophilaSemantic proximity Read

Non-POU Domain-Containing Octamer-Binding Protein Negatively Regulates HIV-1 Infection in CD4 + T CellsSemantic proximity Read

Examining the potential involvement of NONO in TDP-43 proteinopathy in <i>Drosophila</i>Semantic proximity Read

3′UTR Deletion of NONO Leads to Corpus Callosum Anomaly, Left Ventricular Non-Compaction and Ebstein’s Anomaly in a Male FetusSemantic proximity Read

POU Domain Factors in the Neuroendocrine System: Lessons from Developmental Biology Provide Insights into Human DiseaseSemantic proximity Read