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Article

Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis.

PLoS medicine - 1 Sept 2018

Udler Miriam S, Kim Jaegil, von Grotthuss Marcin, Bonàs-Guarch Sílvia, Cole Joanne B, Chiou Joshua, Boehnke Michael, Laakso Markku, Atzmon Gil, Glaser Benjamin, Mercader Josep M, Gaulton Kyle, Flannick Jason, Getz Gad, Florez Jose C

Abstract excerpt

BACKGROUND: Type 2 diabetes (T2D) is a heterogeneous disease for which (1) disease-causing pathways are incompletely understood and (2) subclassification may improve patient management. Unlike other biomarkers, germline genetic markers do not change with disease progression or treatment. In this paper, we test whether a germline genetic approach informed by physiology can be used to deconstruct T2D heterogeneity....

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PMID: 30240442
DOI: 10.1371/journal.pmed.1002654
PMCID: PMC6150463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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