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Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations

10 Jan 2024

Abstract excerpt

Abstract Background Type 2 diabetes (T2D) is a heterogeneous and polygenic disease. Previous studies have leveraged the highly polygenic and pleiotropic nature of T2D variants to partition the heterogeneity of T2D, in order to stratify patient risk and gain mechanistic insight. We expanded on these approaches by performing colocalization across GWAS traits while assessing the causality and directionality of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38200577
DOI: 10.1186/s13073-023-01255-7

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