Article

Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity

2023-09-29

Abstract excerpt

We identified genetic subtypes of type 2 diabetes (T2D) by analyzing genetic data from diverse groups, including non-European populations. We implemented soft clustering with 650 T2D-associated genetic variants, capturing known and novel T2D subtypes with distinct cardiometabolic trait associations. The twelve genetic clusters were distinctively enriched for single-cell regulatory regions. Polygenic scores derived...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3688e49f-3acc-5cb8-a36a-ffacf72e8bd5
DOI: 10.1101/2023.09.28.23296294

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical HeterogeneityDOI 10.1101/2023.09.28.23296294Read

Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical HeterogeneitySemantic proximity Read

Multi-ancestry polygenic mechanisms of type 2 diabetes.Semantic proximity Read

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.Semantic proximity Read

Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complicationsSemantic proximity Read

Clustering of Type 2 Diabetes Genetic Loci by Multi-Trait Associations Identifies Disease Mechanisms and SubtypesSemantic proximity Read

Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis.Semantic proximity Read

High-throughput Genetic Clustering of Type 2 Diabetes Loci Reveals Heterogeneous Mechanistic Pathways of Metabolic DiseaseSemantic proximity Read

Integrated clinical risk prediction of type 2 diabetes with a multifactorial polygenic risk scoreSemantic proximity Read

High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease.Semantic proximity Read

Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation.Semantic proximity Read

Type 2 diabetes polygenic risk score demonstrates context-dependent effects and associations with type 2 diabetes-related risk factors and complications across diverse populationsSemantic proximity Read

Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.Semantic proximity Read