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Article

Partitioned polygenic scores show mechanistic heterogeneity in type 2 diabetes and hypertension comorbidity.

Nature communications - 9 Feb 2026

Pascat Vincent, Zudina Liudmila, Maurin Lucas, Ulrich Anna, Maina Jared G, Demirkan Ayse, Balkhiyarova Zhanna, Pupko Igor, Sharhorodska Yevheniya, Pattou François, Staels Bart, Kaakinen Marika, Khamis Amna, Bonnefond Amélie, Munroe Patricia, Froguel Philippe, Prokopenko Inga

Abstract excerpt

Type 2 diabetes and hypertension are common health conditions that often occur together, suggesting shared biological mechanisms. To explore this relationship, we analyse large-scale multiomic data to uncover genetic factors underlying type 2 diabetes and blood pressure comorbidity. We curate 1304 independent single-nucleotide variants associated with type 2 diabetes and blood pressure, grouping them into five...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

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Source

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Identifiers

PMID: 41663376
DOI: 10.1038/s41467-025-67449-2
PMCID: PMC12886974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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