Article

Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity

2023-10-09

Abstract excerpt

<title>Abstract</title> <p>We identified genetic subtypes of type 2 diabetes (T2D) by analyzing genetic data from diverse groups, including non-European populations. We implemented soft clustering with 650 T2D-associated genetic variants, capturing known and novel T2D subtypes with distinct cardiometabolic trait associations. The twelve genetic clusters were distinctively enriched for single-cell regulatory regio...

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Literature Corpus work: 8880d968-f685-50a7-b435-33ba0a99e014
DOI: 10.21203/rs.3.rs-3399145/v1

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