Article

Mechanistic Heterogeneity in Type 2 Diabetes and Hypertension Comorbidity Revealed with Partitioned Polygenic Scores

2025-03-06

Abstract excerpt

<h4>Summary</h4> Type 2 diabetes (T2D) and hypertension are common health conditions that often occur together, suggesting shared biological mechanisms. To explore this relationship, we analysed large-scale multiomic data to uncover genetic factors underlying T2D and blood pressure (BP) comorbidity. We curated 1,304 independent single-nucleotide variants (SNVs) associated with T2D/BP, grouping them into five clust...

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Literature Corpus work: 2b7ecfdd-6787-5e3a-87ac-6f5ac63db5df
DOI: 10.1101/2025.03.02.25323190

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