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Article

Multi-ancestry polygenic mechanisms of type 2 diabetes.

Nature medicine - 1 Apr 2024

Smith Kirk, Deutsch Aaron J, McGrail Carolyn, Kim Hyunkyung, Hsu Sarah, Huerta-Chagoya Alicia, Mandla Ravi, Schroeder Philip H, Westerman Kenneth E, Szczerbinski Lukasz, Majarian Timothy D, Kaur Varinderpal, Williamson Alice, Zaitlen Noah, Claussnitzer Melina, Florez Jose C, Manning Alisa K, Mercader Josep M, Gaulton Kyle J, Udler Miriam S

Abstract excerpt

Type 2 diabetes (T2D) is a multifactorial disease with substantial genetic risk, for which the underlying biological mechanisms are not fully understood. In this study, we identified multi-ancestry T2D genetic clusters by analyzing genetic data from diverse populations in 37 published T2D genome-wide association studies representing more than 1.4 million individuals. We implemented soft clustering with 650...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38443691
DOI: 10.1038/s41591-024-02865-3
PMCID: PMC11175990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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