Article
Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.
Developmental cell - 14 Aug 2012
Gendrel Anne-Valerie, Apedaile Anwyn, Coker Heather, Termanis Ausma, Zvetkova Ilona, Godwin Jonathan, Tang Y Amy, Huntley Derek, Montana Giovanni, Taylor Steven, Giannoulatou Eleni, Heard Edith, Stancheva Irina, Brockdorff Neil
Abstract excerpt
X chromosome inactivation involves multiple levels of chromatin modification, established progressively and in a stepwise manner during early development. The chromosomal protein Smchd1 was recently shown to play an important role in DNA methylation of CpG islands (CGIs), a late step in the X inactivation pathway that is required for long-term maintenance of gene silencing. Here we show that inactive X chromosome...
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