Article

Cell-type specific molecular signatures of aging revealed in a brain-wide transcriptomic cell-type atlas

2023-07-27

Abstract excerpt

Biological aging can be defined as a gradual loss of homeostasis across various aspects of molecular and cellular function. Aging is a complex and dynamic process which influences distinct cell types in a myriad of ways. The cellular architecture of the mammalian brain is heterogeneous and diverse, making it challenging to identify precise areas and cell types of the brain that are more susceptible to aging than o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 293306c9-c393-54af-bcc8-094bd8d936ad
DOI: 10.1101/2023.07.26.550355

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell-type specific molecular signatures of aging revealed in a brain-wide transcriptomic cell-type atlasDOI 10.1101/2023.07.26.550355Read

A global view of aging and Alzheimer’s pathogenesis-associated cell population dynamics and molecular signatures in the human and mouse brainsSemantic proximity Read

Spatiotemporal profiling reveals the impact of caloric restriction on mammalian brain agingSemantic proximity Read

Cell-specific RNA isoform remodeling in the aging mouse brainSemantic proximity Read

Single-cell, multi-region profiling of the macaque brain across the lifespanSemantic proximity Read

A spatiotemporal map of the aging mouse brain reveals white matter tracts as vulnerable fociSemantic proximity Read

Age-associated transcriptomic and epigenetic alterations in mouse hippocampusSemantic proximity Read

A mitochondrial-immune axis drives the transcriptomic transition from brain aging to Alzheimer’s diseaseSemantic proximity Read

Region-Specific Transcriptional Signatures of Brain Aging in the Absence of Neuropathology at the Single-cell LevelSemantic proximity Read

Zonation-dependent single-endothelial cell transcriptomic changes in the aged brainSemantic proximity Read

Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and genderSemantic proximity Read

Species and Cell-Type Properties of Classically Defined Human and Rodent Neurons and GliaSemantic proximity Read

A Panoramic View of Cell Population Dynamics in Mammalian AgingSemantic proximity Read