Article

cfDecon: Accurate and Interpretable methylation-based cell type deconvolution for cell-free DNA

2025-02-15

Abstract excerpt

Cell-free DNA (cfDNA) analysis has emerged as a powerful tool for noninvasive diagnostics and monitoring of aberrant methylation. However, computational deconvolution of cfDNA remains challenging due to the complexity of methylation data, the diverse cellular compositions in cfDNA mixtures, and the limited interpretability of current methods. We present cfDecon, an efficient deep-learning framework for cfDNA decon...

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Literature Corpus work: aba0b76b-60ed-58cf-928d-7cb8ac34dacc
DOI: 10.1101/2025.02.11.637663

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