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MetDecode: methylation-based deconvolution of cell-free DNA for noninvasive multi-cancer typing

22 Aug 2024

Abstract excerpt

MOTIVATION: Circulating-cell free DNA (cfDNA) is widely explored as a noninvasive biomarker for cancer screening and diagnosis. The ability to decode the cells of origin in cfDNA would provide biological insights into pathophysiological mechanisms, aiding in cancer characterization and directing clinical management and follow-up. RESULTS: We developed a DNA methylation signature-based deconvolution algorithm,...

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PMID: 39177091
DOI: 10.1093/bioinformatics/btae522

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