Article

Multi-cell type deconvolution using a probabilistic model for single-molecule DNA methylation haplotypes

2023-08-21

Abstract excerpt

<h4>Background</h4> Deconvolution is used to estimate the proportion of mixed cell types from tissue or blood samples based on genomic profiling. DNA methylation is commonly used because specific CpG positions reflect cell type identity and can be accurately measured at either the population or single-molecule level. Methylation sequencing techniques can profile multiple individual CpGs on a single DNA molecule,...

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Literature Corpus work: 683b27ad-1d6d-5589-829f-db50a88b3a42
DOI: 10.1101/2023.08.20.554012

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