Tissue informative cell-free DNA methylation sites in amyotrophic lateral sclerosis

Abstract excerpt

Cell-free DNA (cfDNA) is increasingly recognized as a promising biomarker candidate for disease monitoring. However, its utility in neurodegenerative diseases, like amyotrophic lateral sclerosis (ALS), remains underexplored. Existing biomarker discovery approaches are tailored to a specific disease context or are too expensive to be clinically practical. Here, we address these challenges through a new approach com...

Topics

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• Amyotrophic Lateral Sclerosis
• Amyotrophic Lateral Sclerosis Research
• Blood Cells
• C9orf72 Protein
• Epigenome
• Mutation
• NAV1.7 Voltage-Gated Sodium Channel
• RNA-Binding Protein FUS

Identifiers and source

Literature Corpus work

a947dda2-9dc7-5ed2-b36b-c32e6f93244e

DOI

10.1101/2024.04.08.24305503