Article

cfMIND: A read-level methylation framework for accurate non-invasive disease detection using cell-free DNA

2026-05-16

Abstract excerpt

Plasma cell-free DNA (cfDNA) emerged as a promising non-invasive biomarker for cancers. However, reliable detection remains challenging due to the low abundance of tumor-derived cfDNA fragments and the dilution of informative methylation signals when aggregated into region-level features. Here, we propose a novel approach cfMIND, an efficient and robust machine-learning framework that leverages stratified read-lev...

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Literature Corpus work: c9d634f7-8500-54d0-b130-4a91698f75d2
DOI: 10.64898/2026.05.13.725033

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